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The Biophilia Intruder has been used to treat a wider range of skin diseases.
The Biophilia Intruder has an axial resolution of 30 µm. Its application allows for the study of the epidermis at both the cellular and subcellular levels.
Dec 26th,2025
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The Biophilia Intruder has an axial resolution of 30 µm. Its application allows for the study of the epidermis at both the cellular and subcellular levels.Today, the research goals and limitations of three-dimensional NLS ultramicroscopy in dermatology have become very broad.The following have become a reality:- Evaluating the treatment efficacy of diseases characterized by scleroderma (localized scleroderma, generalized scleroderma), edema (lipoid scleroderma), and chronic inflammatory skin diseases (psoriasis);- Measuring the extent of skin tumor invasion and monitoring post-operative care for surgical interventions, melanoma, basaloid carcinoma, hemangioma, fibroma, and seborrheic keratosis after cryotherapy and laser treatment;- Studying the effects of topical and systemic drugs on the skin (corticosteroids, estradiol).Depending on the methodology, NLS ultramicroscopy diagnosis of skin diseases must be performed by comparing the affected area with healthy skin in the contralateral homologous area.In NLS imaging using a 4.9 GHz nonlinear sensor, normal skin is represented by three layers: the epidermis, dermis, and subcutaneous tissue. The regional and age-related characteristics of skin thickness primarily depend on dermal thickness, which in turn depends on its collagen content.Visualization of the normal epidermis is considered poor in NLS studies using a 1.4 GHz sensor because its actual thickness is 0.02–0.5 mm, a resolution limitation of such systems.The epidermis is a moderately chromogenic structure (Fleindler grade 2–3), and its chromogenicity depends on the thickness of the stratum corneum and the rate of desquamation.Ultra-high frequency nonlinear sensors can study more of the superficial papillary layer of the dermis and the underlying reticular layer, the latter characterized by a more homogeneous structure.For the differential diagnosis of skin tumors such as hemangiomas or melanomas, the ultramicroscopic scanning combined with spectral entropy analysis (SEA) mode can be successfully applied.
